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American Society of Nephrology. New York Medical Journal. Physiological changes caused by cocaine withdrawal include vivid and unpleasant dreams, insomnia or hypersomnia, increased appetite and psychomotor retardation or agitation. The study points to several areas of future research, including differences across gender in binge behavior and its correlates, heterogeneity in crack use patterns and their relation to sexual risk behaviors, measurement of crack use patterns and trajectories over time, and potential enhancements for sexual risk-reduction among HIV-positive crack users. The rectum and the vaginal canal is where the majority of the drug would be taken up through the membranes lining its walls. Archived from the original on 1 January

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The Journal of Neuroscience.

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Coca teaan infusion of coca leaves, is also a traditional method of consumption. Table 1 shows reported descriptors of a typical crack binge and the last binge. Karl Koller a close associate of Sigmund Freudwho would write about cocaine later experimented with cocaine for ophthalmic usage. Whether these strains are natural mutations or the product of human tampering is unclear. This study describes binge use of crack cocaine, binge users, and their sexual risk behaviors in a sample of African-American, HIV-positive users. The drug is then absorbed by the membranes of these body parts.

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